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Journal of Clinical Pathology 1973;26:678-683; doi:10.1136/jcp.26.9.678
Copyright © 1973 by the BMJ Publishing Group Ltd & Association of Clinical Pathologists.

Enzymes involved in phenylalanine metabolism in the human foetus and child

Anne McLean, Margaret J. Marwick, Barbara E. Clayton

Department of Chemical Pathology, The Hospital for Sick Children, Great Ormond Street, London
Institute of Child Health, Guilford Street, London

The activities of phenylalanine p-hydroxylase, tyrosine: alpha-ketoglutarate and phenylalanine: pyruvate aminotransferases, and aromatic alpha-ketoacid reductase have been measured in liver biopsies obtained from children with a series of disorders other than phenylketonuria and from human foetuses aged 8·5 to 24 weeks. The importance of such a study in relation to the management of infants with hyperphenylalaninaemia and pregnant phenylketonuric women is discussed


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This article has been cited by other articles:

  • Liechty, E. A., Boyle, D. W., Moorehead, H., Auble, L., Denne, S. C. (1999). Aromatic Amino Acids Are Utilized and Protein Synthesis Is Stimulated during Amino Acid Infusion in the Ovine Fetus. J. Nutr. 129: 1161-1166 [Abstract] [Full Text]  

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