The distribution of muramidase (lysozyme) in human tissues.

D Y Mason, C R Taylor

The distribution of muramidase (lysozyme) in normal and pathological human tissues has been studied, using an immunohistological technique. The enzyme was demonstrated in a variety of healthy tissues, including serous salivary acinar cells, lactating mammary tissue, Paneth cells, renal tubular cells, myeloid cells (including eosinophils), and histiocytic cells. In pathological tissues the most striking positivity was encountered in reactive histiocytic cells in granulomatous conditions such as tuberculosis and Crohn's disease. The finding of this study are related to previous reports of the distribution of human and animal muramidase and the implications of patterns of muramidase staining in pathological histiocytes are briefly discussed.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Deckers, D., Vanlint, D., Callewaert, L., Aertsen, A., Michiels, C. W. (2008). Role of the Lysozyme Inhibitor Ivy in Growth or Survival of Escherichia coli and Pseudomonas aeruginosa Bacteria in Hen Egg White and in Human Saliva and Breast Milk. Appl. Environ. Microbiol. 74: 4434-4439 [Abstract] [Full Text]  
• Zhang, K., Gao, R., Zhang, H., Cai, X., Shen, C., Wu, C., Zhao, S., Yu, L. (2005). Molecular Cloning and Characterization of Three Novel Lysozyme-Like Genes, Predominantly Expressed in the Male Reproductive System of Humans, Belonging to the C-Type Lysozyme/Alpha-Lactalbumin Family. Biol. Reprod. 73: 1064-1071 [Abstract] [Full Text]  
• Cunliffe, R. N., Mahida, Y. R. (2004). Expression and regulation of antimicrobial peptides in the gastrointestinal tract. J. Leukoc. Biol. 75: 49-58 [Abstract] [Full Text]  
• Cunliffe, R N, Rose, F R A J, Keyte, J, Abberley, L, Chan, W C, Mahida, Y R (2001). Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease. Gut 48: 176-185 [Abstract] [Full Text]  
• Strobl, H., Scheinecker, C., Riedl, E., Csmarits, B., Bello-Fernandez, C., Pickl, W. F., Majdic, O., Knapp, W. (1998). Identification of CD68+lin- Peripheral Blood Cells with Dendritic Precursor Characteristics. J. Immunol. 161: 740-748 [Abstract] [Full Text]  
• Strobl, H., Bello-Fernandez, C., Riedl, E., Pickl, W. F., Majdic, O., Lyman, S. D., Knapp, W. (1997). flt3 Ligand in Cooperation With Transforming Growth Factor-beta 1 Potentiates In Vitro Development of Langerhans-Type Dendritic Cells and Allows Single-Cell Dendritic Cell Cluster Formation Under Serum-Free Conditions. Blood 90: 1425-1434 [Abstract] [Full Text]  
• Goldstein, N. S., Ritter, J. H., Argenyi, Z. B., Wick, M. R. (1995). Granulocytic Sarcoma: Potential Diagnostic Clues From Immunostaining Patterns Seen With Anti-Lymphoid Antibodies. INT J SURG PATHOL 2: 177-186 [Abstract]  
• Van Dyke, T. E., Hoop, G. A. (1990). Neutrophil Function And Oral Disease. CROBM 1: 117-133 [Full Text]  
• McGrae, J. D. Jr (1986). Actinic Granuloma: A Clinical, Histopathologic, and Immunocytochemical Study. Arch Dermatol 122: 43-47 [Abstract]  
• Dahl, M. V. (1986). Is Actinic Granuloma Really Granuloma Annulare?. Arch Dermatol 122: 39-40 [Abstract]  
• Kerdel, F. A., MacDonald, D. M. (1984). Pagetoid Reticulosis: Histiocyte Marker Studies. Arch Dermatol 120: 76-79 [Abstract]  
• Burgdorf, W., Moreland, A., Wasik, R. (1982). Negative Immunoperoxidase Staining for Lysozyme in Nodular Subepidermal Fibrosis. Arch Dermatol 118: 241-243 [Abstract]  
• Rennie, I. G., Parsons, M. A. (1981). Lysozyme Distribution in Human Lacrimal Glands and Other Ocular Adnexa. Arch Ophthalmol 99: 1850-1853 [Abstract]