Postsplenectomy sepsis 10 years or more after operation.

D I Evans

Three new cases (two fatal) of postsplenectomy sepsis occurring 14, 25, and 26 years after operation for hereditary spherocytosis are described. There are now 25 cases in the published work in which this complication occurred 10 or more years after operation, 14 of which were fatal. The mean age of onset is 37 years. The features of the disease are similar to those seen in other postsplenectomy infections, and pneumococcal infection was responsible in 19 cases (76%). The major predisposing illnesses were trauma, hereditary spherocytosis, and idiopathic thrombocytopenia.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Newland, A., Provan, D., Myint, S. (2005). Preventing severe infection after splenectomy. BMJ 331: 417-418 [Full Text]  
• Bolton-Maggs, P H B (2004). Hereditary spherocytosis; new guidelines. Arch. Dis. Child. 89: 809-812 [Full Text]  
• Kang, Y.-S., Kim, J. Y., Bruening, S. A., Pack, M., Charalambous, A., Pritsker, A., Moran, T. M., Loeffler, J. M., Steinman, R. M., Park, C. G. (2004). The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen. Proc. Natl. Acad. Sci. USA 101: 215-220 [Abstract] [Full Text]  
• Breukels, M. A., Zandvoort, A., van den Dobbelsteen, G. P. J. M., van den Muijsenberg, A., Lodewijk, M. E., Beurret, M., Klok, P. A., Timens, W., Rijkers, G. T. (2001). Pneumococcal Conjugate Vaccines Overcome Splenic Dependency of Antibody Response to Pneumococcal Polysaccharides. Infect. Immun. 69: 7583-7587 [Abstract] [Full Text]  
• Bader-Meunier, B., Gauthier, F., Archambaud, F., Cynober, T., Mielot, F., Dommergues, J.-P., Warszawski, J., Mohandas, N., Tchernia, G. (2001). Long-term evaluation of the beneficial effect of subtotal splenectomy for management of hereditary spherocytosis. Blood 97: 399-403 [Abstract] [Full Text]  
• del Giudice, E. M., Perrotta, S., Nobili, B., Specchia, C., d'Urzo, G., Iolascon, A. (1999). Coinheritance of Gilbert Syndrome Increases the Risk for Developing Gallstones in Patients With Hereditary Spherocytosis. Blood 94: 2259-2262 [Abstract] [Full Text]  
• Burkhart, H. M., Wilcox, M. G., Sawchuk, A. P. (1997). Humoral Immunity After Splenorenal Artery Bypass. VASC ENDOVASCULAR SURG 31: 543-546 [Abstract]  
• Karrer, U., Althage, A., Odermatt, B., Roberts, C. W.M., Korsmeyer, S. J., Miyawaki, S., Hengartner, H., Zinkernagel, R. M. (1997). On the Key Role of Secondary Lymphoid Organs in Antiviral Immune Responses Studied in Alymphoplastic (aly/aly) and Spleenless (Hox11-/-) Mutant Mice. JEM 185: 2157-2170 [Abstract] [Full Text]  
• , (1996). Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. BMJ 312: 430-434 [Full Text]  
• Billiar, T. R., West, M. A., Hyland, B. J., Simmons, R. L. (1988). Splenectomy Alters Kupffer Cell Response to Endotoxin. Arch Surg 123: 327-332 [Abstract]  
• SIBER, G. R., GORHAM, C., MARTIN, P., CORKERY, J. C., SCHIFFMAN, G. (1986). Antibody Response to Pretreatment Immunization and Post-treatment Boosting with Bacterial Polysaccharide Vaccines in Patients with Hodgkin's Disease. ANN INTERN MED 104: 467-475 [Abstract]