Severe cutaneous reactions to captopril and enalapril; histological study and comparison with early mycosis fungoides.

P N Furness, M J Goodfield, K A MacLennan, A Stevens, L G Millard

A severe non-dose related skin eruption attributable to treatment with captopril was recently reported: this is distinct from the dose related rashes that have been widely described. Ultrastructural and immunohistochemical studies were carried out to determine in detail the histological features of this eruption: the histological appearances were similar to those found in early mycosis fungoides, so that this disease was erroneously diagnosed in one case. Unlike most other complications resulting from treatment with Captopril, an indistinguishable rash can result from treatment with enalapril, a newer angiotensin converting enzyme inhibitor.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Grossman, E, Messerli, F.H, Goldbourt, U (2001). Antihypertensive therapy and the risk of malignancies. Eur Heart J 22: 1343-1352 [Abstract]  
• Saeed, S A M, Bazza, M, Zaman, M, Ryatt, K S (2000). Cefuroxime induced lymphomatoid hypersensitivity reaction. Postgrad. Med. J. 76: 577-579 [Abstract] [Full Text]  
• Westhoven, G. S., Fretzin, S., Lewis, C. (1997). A Woman With Lung Cancer and Exfoliative Dermatitis. Arch Dermatol 133: 499-500 [Abstract]  
• Callot, V., Roujeau, J.-C., Bagot, M., Wechsler, J., Chosidow, O., Souteyrand, P., Morel, P., Dubertret, L., Avril, M.-F., Revuz, J. (1996). Drug-Induced Pseudolymphoma and Hypersensitivity Syndrome: Two Different Clinical Entities. Arch Dermatol 132: 1315-1321 [Abstract]  
• Crowson, A. N., Magro, C. M. (1995). Antidepressant Therapy: A Possible Cause of Atypical Cutaneous Lymphoid Hyperplasia. Arch Dermatol 131: 925-929 [Abstract]  
• Israili, Z. H., Hall, W. D. (1992). Cough and Angioneurotic Edema Associated with Angiotensin-Converting Enzyme Inhibitor Therapy: A Review of the Literature and Pathophysiology. ANN INTERN MED 117: 234-242 [Abstract]