Aberrant phenotypes in peripheral T cell lymphomas.

N Hastrup, E Ralfkiaer, G Pallesen

Laboratory of Immunohistology, Aarhus Kommunehospital, University of Aarhus, Denmark.

Seventy six peripheral T cell lymphomas were examined immunohistologically to test their reactivity with a panel of monoclonal antibodies against 11 T cell associated antigens (CD1-8, CD27, UCHL1, and the T cell antigen receptor). Sixty two (82%) lymphomas showed aberrant phenotypes, and four main categories were distinguished as follows: (i) lack of one or several pan-T cell antigens (49, 64% of the cases); (ii) loss of both the CD4 and CD8 antigens (11, 15% of the cases); (iii) coexpression of the CD4 and CD8 antigens (13, 17% of the cases); and (iv) expression of the CD1 antigen (eight, 11% of the cases). No correlation was seen between the occurrence of aberrant phenotypes and the histological subtype. It is concluded that the demonstration of an aberrant phenotype is a valuable supplement to histological assessment in the diagnosis of peripheral T cell lymphomas. It is recommended that the panel of monoclonal antibodies against T cell differentiation antigens should be fairly large, as apparently any antigen may be lost in the process of malignant transformation.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Mattoch, I. W., Fulton, R., Kim, Y., Hoppe, R., Warnke, R. A., Sundram, U. N. (2009). Cutaneous Peripheral T-Cell Lymphoma Associated With a Proliferation of B Cells. Am J Clin Pathol 131: 810-819 [Abstract] [Full Text]  
• Cuadros, M., Dave, S. S., Jaffe, E. S., Honrado, E., Milne, R., Alves, J., Rodriguez, J., Zajac, M., Benitez, J., Staudt, L. M., Martinez-Delgado, B. (2007). Identification of a Proliferation Signature Related to Survival in Nodal Peripheral T-Cell Lymphomas. JCO 25: 3321-3329 [Abstract] [Full Text]  
• Went, P., Agostinelli, C., Gallamini, A., Piccaluga, P. P., Ascani, S., Sabattini, E., Bacci, F., Falini, B., Motta, T., Paulli, M., Artusi, T., Piccioli, M., Zinzani, P. L., Pileri, S. A. (2006). Marker Expression in Peripheral T-Cell Lymphoma: A Proposed Clinical-Pathologic Prognostic Score. JCO 24: 2472-2479 [Abstract] [Full Text]  
• Richardson, S., Budgin, J. B., Junkins-Hopkins, J. M., Vittorio, C. C., Lee, J., Miller, W. T. Jr, Rook, A. H., Kim, E. J. (2005). Low-Dose Bexarotene and Low-Dose Interferon Alfa-2b for Adult T-Cell Leukemia/Lymphoma Associated With Human T-Lymphotropic Virus 1. Arch Dermatol 141: 301-304 [Full Text]  
• Pileri, S A, Ascani, S, Leoncini, L, Sabattini, E, Zinzani, P L, Piccaluga, P P, Pileri, A Jr, Giunti, M, Falini, B, Bolis, G B, Stein, H (2002). Hodgkin's lymphoma: the pathologist's viewpoint. J. Clin. Pathol. 55: 162-176 [Abstract] [Full Text]  
• Goldstein, N. S., Ritter, J. H., Argenyi, Z. B., Wick, M. R. (1995). Granulocytic Sarcoma: Potential Diagnostic Clues From Immunostaining Patterns Seen With Anti-Lymphoid Antibodies. INT J SURG PATHOL 2: 177-186 [Abstract]