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Journal of Clinical Pathology 1993;46:83-85; doi:10.1136/jcp.46.1.83
Copyright © 1993 by the BMJ Publishing Group Ltd & Association of Clinical Pathologists.

Electron microscopic and immunohistochemical findings in a case of olfactory neuroblastoma.

Z M Du, Y S Li, B F Wang

Department of Pathology, Fourth Military Medical University, Xi'an Shaanxi, People's Republic of China.

A case of olfactory neuroblastoma is reported. Light microscopic examination showed various arrangements of poorly differentiated tumour cells forming either uniform sheets or convoluted cords of multiple cell layers orientated toward a richly vascular stroma. Electron microscopic examination showed the presence of abundant cytoplasmic filaments and processes, and dense core endocrine vesicles ranging from 100-160 nm in diameter in both the perinuclear region and tumour cell processes. Immunohistochemical staining was positive in most of the tumour cells for neuron specific enolase, and in a few cells for S-100 protein, vimentin, and serotonin, but staining for desmin and keratin produced no reaction.


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