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Vaccination to prevent varicella and shingles

J Breuer

Department of Virology, St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, 37 Ashfield Street, London E1 1BB, UK

Correspondence to:
Dr Breuer j.breuer{at}mds.qmw.ac.uk

Vaccination of healthy children against varicella using the live attenuated Oka vaccine has been available in Japan and south Korea for several years. In 1996, a programme of universal vaccination of children to prevent varicella was introduced in the USA and other countries, including Canada, Germany, and Sweden, have licensed the vaccine for use in healthy children. This article reviews the origin of the Oka vaccine and the evidence for vaccine safety and efficacy in children and adults. Universal vaccination of children and targeted vaccination of groups at risk of severe varicella are discussed. The possible use of the Oka vaccine to prevent zoster is reviewed, and initiatives to develop new varicella zoster virus vaccines are outlined.

Key Words: chickenpox • varicella zoster • herpes zoster • vaccination • leukaemia

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This article has been cited by other articles:

• Maple, P. A. C., Gray, J., Breuer, J., Kafatos, G., Parker, S., Brown, D. (2006). Performance of a Time-Resolved Fluorescence Immunoassay for Measuring Varicella-Zoster Virus Immunoglobulin G Levels in Adults and Comparison with Commercial Enzyme Immunoassays and Merck Glycoprotein Enzyme Immunoassay. CVI 13: 214-218 [Abstract] [Full Text]  
• Holzel, H (2002). Grand Round Presentation. J. Clin. Pathol. 55: 487-487 [Full Text]  
• Katona, S J, Breuer, J (2002). Vaccination to prevent varicella and shingles. J. Clin. Pathol. 55: 399-399 [Full Text]