© 2001 Journal of Clinical Pathology
Short report
Wegener's granulomatosis presenting as acute suppurative interstitial nephritis
Department of Renal Medicine, Lister Hospital, Coreys Mill Lane, Stevenage, Hertfordshire SG1 4AB, UK
Department of Molecular and Diagnostic Histopathology, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 2QQ, UK
Correspondence to:
Dr Farrington Dr.FARRINGTON{at}lister.enherts-tr.nhs.uk
A 78 year old man presented with acute renal failure following a prolonged respiratory illness. A renal biopsy demonstrated severe suppurative interstitial nephritis with normal glomeruli. After nine weeks of antibiotics he remained anuric and a second biopsy demonstrated pauci-immune, necrotising glomerulonephritis. His subsequent clinical course was consistent with a diagnosis of Wegener's granulomatosis and antineutrophil cytoplasmic antibodies (ANCA) were detected. This is the first reported case of Wegener's granulomatosis presenting with an isolated tubulointerstitial lesion.
Key Words: antineutrophil cytoplasmic antibody • pyelonephritis • Wegener's granulomatosis
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Compound via MeSHSubstance via MeSHHazardous Substances DB CYCLOPHOSPHAMIDEPREDNISONEMedline Plus Health Information Wegener's Granulomatosis
Topic Collections
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Interstitial lung disease
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Vascularitis
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Clinical diagnostic tests
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Immunology (including allergy)
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TB and other respiratory infections
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