REVIEW

NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system?

L Van Heerebeek⁴, C Meischl², W Stooker³, C J L M Meijer¹, H W M Niessen¹, D Roos²

¹ Department of Pathology, Free University Medical Center, PO Box 7057, 1007 MB Amsterdam, 1006 AD Amsterdam, The Netherlands
² Central Laboratory of the Netherlands Blood Transfusion Service (CLB) and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, The Netherlands
³ Department of Cardiac Surgery, Free University Medical Center,
⁴ Institute of Cardiovascular Research, Free University Medical Center

Correspondence to:
Correspondence to:
Dr H W M Niessen, Department of Pathology, Free University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands;
jwm.niessen{at}vumc.nl

Reactive oxygen species play an important role in a variety of (patho)physiological vascular processes. Recent publications have produced evidence of a role for putative non-phagocyte NADP oxidase(s) in the vascular production of reactive oxygen species. In the present review, we discuss the detection of the different components of NADP oxidase(s) in the vascular system, together with the putative role of reactive oxygen species produced by vascular NADPH oxidase(s), in both in vitro and in vivo studies.

Keywords: NADPH oxidase; phagocytes; reactive oxygen species; atherosclerosis

Abbreviations: Ang, angiotensin; CAD, coronary artery disease; CGD, chronic granulomatous disease; DPI, diphenylene iodonium; ER, endoplasmic reticulum; HUVEC, human umbilical vein endothelial cell; LPS, lipopolysaccharide; PMA, phorbol-12-myristate-13-acetate; ROS, reactive oxygen species; RT-PCR, reverse transcriptase polymerase chain reaction; SMC, smooth muscle cell; TNF-, tumour necrosis factor ; VSMC, vascular smooth muscle cell

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