ORIGINAL ARTICLE

Prognostic significance of grading (MIB-1 system) in patients with myxoid liposarcoma

U Tateishi¹, T Hasegawa², Y Beppu³, A Kawai³, N Moriyama¹

¹ Division of Diagnostic Radiology, National Cancer Centre Hospital, Tsukiji, Chuo-Ku, 104–0045, Tokyo, Japan
² Division of Pathology, National Cancer Centre Hospital
³ Division of Orthopaedics, National Cancer Centre Hospital

Correspondence to:
Correspondence to:
Dr U Tateishi, Division of Diagnostic Radiology, National Cancer Centre Hospital, Tsukiji, Chuo-Ku, 104–0045, Tokyo, Japan;
utateish{at}ncc.go.jp

Aims: To determine the relation between clinical outcome and tumour grade defined by a MIB-1 (Ki-67) score based grading system.

Method: The clinical and pathological features of 50 patients with myxoid liposarcoma were evaluated, and MIB-1 immunostaining was performed to grade these patients’ tumours. Univariate and multivariate analyses were conducted to evaluate survival. Clinical follow up details were available for all patients (median, 46.5 months; range, 9–408).

Results: Univariate analysis revealed that the tumour site (p < 0.05), round cell component content (p < 0.01), necrosis (p < 0.01), mitosis (p < 0.01), MIB-1 labelling index (p < 0.001), and tumour grade (p < 0.001) had a significant impact on overall survival. Multivariate analysis showed that, of the variables evaluated, the tumour grade defined by a MIB-1 score based grading system was the most significant adverse prognostic factor.

Conclusion: Tumour grade determined by the grading system using the MIB-1 score (MIB-1 system) is a very strong prognostic factor in patients with myxoid liposarcoma.

Keywords: MIB-1; myxoid liposarcoma; prognosis

Abbreviations: HPF, high power field; LI, labelling index; NCC, National Cancer Centre; RC, round cell; RR, relative risk

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