SHORT REPORT

Influence of recipient and donor IL-1, IL-4, and TNF genotypes on the incidence of acute renal allograft rejection

H Lee¹, B Clark¹, H C Gooi¹, J Stoves², C G Newstead²

¹ Department of Transplantation Immunology, St James’s University Hospital, Leeds, LS9 7TF, UK
² Renal Transplant Unit, St James’s University Hospital

Correspondence to:
Correspondence to:
Dr H Lee
Transplantation Laboratory, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK; helena.lee{at}cmmc.nhs.uk

Aims: To determine whether polymorphisms of the genes encoding donor or recipient interleukin 1 (IL-1), tumour necrosis factor (TNF), or IL-4 have any impact on the incidence of acute rejection after renal transplantation.

Methods: All donors and recipients were genotyped for three polymorphisms in the three cytokine genes: IL1A -889, TNFA -308, and IL4 –590.

Results: Statistical analysis of the data obtained revealed no association between the cytokine gene polymorphisms tested and the incidence of post-transplant acute rejection. After stratification for human leucocyte antigen (HLA) matching, it was found that kidneys from donors positive for the TNFA-A allele had a significantly increased incidence of acute rejection in HLA-DR mismatched transplants.

Conclusions: This finding argues for prospective TNFA genotyping of renal donors, with avoidance of allocation of kidneys from donors positive for the TNFA-A allele to HLA-DR mismatched recipients.

Keywords: acute renal allograft rejection; donor cytokine genotype; recipient cytokine genotype

Abbreviations: IL, interleukin; HLA, human leucocyte antigen; MHC, major histocompatibility complex; PCR, polymerase chain reaction; TNF, tumour necrosis factor

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