SHORT REPORT
B-type natriuretic peptide in reversible myocardial ischaemia
1 Department of Clinical Chemistry, New Cross Hospital, Wolverhampton, UK
2 Department of Cardiology, New Cross Hospital, Wolverhampton, UK
3 Research Institute, Healthcare Sciences, Wolverhampton University, Wolverhampton, UK
Correspondence to:
Correspondence to:
R Gama
Department of Clinical Chemistry, New Cross Hospital, Wolverhampton, West Midlands WV10 0QP, UK; rousseau.gama{at}rwh-tr.nhs.uk
Background: Coronary heart disease is associated with increased B-type natriuretic peptides (BNPs), and, although controversial, may cause exaggerated exercise-induced BNP secretion. We investigated BNP in relation to reversible myocardial ischaemia.
Materials and methods: Serum N-terminal proBNP (NT-proBNP) was measured before and after an exercise electrocardiogram test (ETT) in 14 patients with and 45 patients without exercise-induced myocardial ischaemia. Statistical analysis was carried out on logarithmically transformed data. Results, however, are pre-transformed data.
Results: NT-proBNP increased with exercise both in ETT-positive patients (mean (SD) 71.4 (41.2) v 76.8 (44.0) ng/l; p<0.001) and ETT-negative patients (54.0 (61.2) v 60.1 (69.0) ng/l; p<0.001). Pre-exercise and post-exercise NT-proBNP were higher (p<0.05) in ETT-positive than in ETT-negative patients. Incremental NT-proBNP was similar in ETT-positive (4.7 (4.2) ng/l) and ETT-negative (6.2 (8.6) ng/l) patients.
Conclusion: Serum NT-proBNP concentrations are higher in patients with exercise-induced myocardial ischaemia than in those without. Exercise-induced electrocardiographic myocardial ischaemia, however, is not associated with exaggerated BNP secretion.
Abbreviations: BNP, B-type natriuretic peptide; CHD, Coronary heart disease; ETT, electrocardiogram test; NT-proBNP, N-terminal proBNP
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