Journal of Clinical Pathology 2007;60:185-189
ORIGINAL ARTICLE
Value of ezrin, maspin and nm23-H1 protein expressions in predicting outcome of patients with head and neck squamous-cell carcinoma treated with radical radiotherapy
1 Department of Pathology, Geneva University Hospital, Geneva, Switzerland
2 Division of Head and Neck Surgery, Geneva University Hospital, Geneva, Switzerland
3 Division of Radiation Oncology, Geneva University Hospital, Geneva, Switzerland
Correspondence to:
Dr P Mhawech-Fauceglia
Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA; pmhawech1{at}yahoo.com
Background: Prognostic factors in predicting outcomes in patients with head and neck squamous-cell carcinoma (HNSCC) are limited to the clinical–pathological parameters, including lymph node metastasis, location, grade and stage of the disease.
Aim: To determine whether the expression of these proteins has a value in predicting patient outcome.
Methods: Ezrin, maspin and nm23-H1 immunohistochemistry in tissue samples of 120 patients with HNSCC were evaluated using the microarray technique.
Results: In determining the association among each of the three proteins and the clinical–pathological parameters, low maspin expression was the only one found to be significantly associated with high tumour grade (p = 0.007); all others showed no significant associations. In univariate analysis, patients with tumours expressing high ezrin had a shorter disease-free survival (DFS) of 51% than those with low ezrin expression (DFS 84%; p = 0.08). In multivariate analysis, tumours with the combination of loss of maspin and low histological grade had longer DFS (83%) compared with those with high maspin and high histological grade (DFS 42%; p = 0.08).
Conclusion: Our study is the first to determine the value of ezrin and maspin in HNSCC in a large series of patients with long follow-up. Ezrin and maspin seem to have a potential prognostic value in patients with HNSCC but results should be confirmed with further studies.
Abbreviations: DFS, disease-free survival; HNSCC, head and neck squamous-cell carcinoma; IHC, immunohistochemical analysis
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
jcp.2006.036624v1
jcp.2006.036624v2
jcp.2006.036624v3
60/2/185 most recent - Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
- PubMed Citation
- Articles by Mhawech-Fauceglia, P.
- Articles by Allal, A. S
- Pubmed/NCBI databases
Medline Plus Health Information 
Head and Neck Cancer
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
