CASE REPORTS
Adenomatoid tumour of the liver
1 Department of Surgery, Nakabaru Hospital, Fukuoka, Japan
2 Department of Anatomic Pathology, Hamanomachi Hospital, Fukuoka, Japan
3 Department of Surgery, Oita Red Cross Hospital, Oita, Japan
4 Department of Roentgenology, Oita Red Cross Hospital, Oita, Japan
5 Department of Anatomic Pathology, Oita Red Cross Hospital, Oita, Japan
Correspondence to:
Dr S Nagata, Department of Surgery, Nakabaru Hospital, 6 Mitarai, Kasuya 811-2206, Japan; ngkkd637{at}yahoo.co.jp
An unusual primary adenomatoid tumour arising in the normal liver is described. Hepatectomy was performed, and the patient is alive and free of disease 1 year postsurgery. Grossly, the tumour showed a haemorrhagic cut surface with numerous microcystic structures. Histological examination revealed cystic or angiomatoid spaces of various sizes lined by cuboidal, low-columnar, or flattened epithelioid cells with vacuolated cytoplasm and round to oval nuclei. The epithelioid cells were entirely supported by proliferated capillaries and arteries together with collagenous stroma. Immunohistochemical studies showed that the epithelioid cells were strongly positive for a broad spectrum of cytokeratins (AE1/AE3, CAM5.2, epithelial membrane antigen and cytokeratin 7) and mesothelial markers (calretinin, Wilms’ tumour 1 and D2-40). These cells were negative for Hep par-1, carcinoembryonic antigen, neural cell adhesion molecule, CD34, CD31 and HMB45. Atypically, abundant capillaries were observed; however, the cystic proliferation of epithelioid cells with vacuoles and immunohistochemical profile of the epithelioid element were consistent with hepatic adenomatoid tumour.
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