Journal of Clinical Pathology 2008;61:1041-1044
ORIGINAL ARTICLES
Human papillomaviruses do not play an aetiological role in Müllerian adenosarcomas of the uterine cervix
1 Division of Anatomical Pathology, School of Pathology, University of the Witwatersrand, Johannesburg and the National Health Laboratory Service, Republic of South Africa
2 Division of Anatomic Pathology, Department of Pathology, University of Vermont, Burlington, Vermont, USA
Dr W Grayson, Suite 308, Private Bag X11, Craighall, 2024, South Africa; wayne.grayson{at}live.com
Aim: To determine if human papillomaviruses (HPVs) play a role in the histogenesis of adenosarcomas of the uterine cervix.
Methods: Nine archival cases of primary cervical adenosarcoma were studied. The HPV status of the nine histologically proven tumours was investigated by non-isotopic in situ hybridisation (NISH) and PCR. NISH was performed using digoxigenin labelled probes to HPV types 6, 11, 16, 18, 31 and 33. PCR used GP5+/GP6+ primers to the HPV L1 gene.
Results: Neither the benign epithelial components nor the malignant stromal components of the 9 neoplasms harboured nuclear NISH signals for the HPV types investigated. Amplimers of the HPV L1 gene were not detected by PCR in any of the tumours studied.
Conclusion: HPVs do not appear to play an aetiological role in cervical adenosarcomas. This suggests that a different histogenetic pathway for this rare tumour type must exist.
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