© 2002 Journal of Clinical Pathology
EDITORIAL
HPV
Self testing for human papillomaviruses
Correspondence to:
Correspondence to:
C S Herrington, Department of Pathology, University of Liverpool, Royal Liverpool University Hospital, Duncan Building, Daulby Street, Liverpool L69 3GA, UK;
c.s.herrington@liv.ac.uk
Is it feasible and what samples should be used?
Keywords: human papillomavirus; cervical screening; high grade intraepithelial lesions; cervical cancer
Abbreviations: HPV, human papillomavirus; PCR, polymerase chain reaction
A great deal has been written about the potential value of human papillomavirus (HPV) testing, particularly in the context of cervical screening programmes. Much of the published literature has focused on the assessment of specific patient groups, particularly women with mildly abnormal cervical smears, in an attempt to identify those women at greatest risk of either possessing or developing a high grade intraepithelial lesion which, according to current guidelines, requires treatment. Much of the value of HPV testing is dependent upon its high sensitivity for the detection of high grade disease and also the high negative predictive value of testing women both with low grade cytological abnormalities and in the context of primary screening.1–4 However, the duration of protection of a negative result is not yet known. These points are among those covered by the systematic review of the role of HPV testing within a cervical screening programme, published
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