© 2002 Journal of Clinical Pathology
EDITORIAL
Tissue microarrays
Tissue microarrays for predictive molecular pathology
Institute of Pathology, University of Basel, Schönbeinstrasse 40, CH-4031 Basel, Switzerland
Correspondence to:
Correspondence to:
Dr G Sauter, Institute of Pathology, University of Basel, Schoenbeinstrasse 40, CH-4031 Basel, Switzerland;
Guido.Sauter@unibas.ch
Preparing for a TITANIC problem
Keywords: immunohistochemistry; tissue microarray; quality control
| The first 150 words of the full text of this article appear below. |
The advent of a novel category of anticancer drugs targeting individual genes is greatly affecting pathology and it appears that a new discipline—predictive molecular pathology—will become important in our field. For example, Herceptin (trastuzamab) treatment can only be used against tumours expressing the HER-2 oncogene1 and STI571 (Glivec) is highly efficient against tumours expressing c-kit (CD117).2 Because these target genes can be expressed in many different tumour types, oncologists are now increasingly demanding HER-2 and c-kit analyses for all of their patients so that they can potentially benefit from new drugs. The number of such analyses, often performed many years after the removal of the primary tumour, increases rapidly as more patients with cancer and clinicians become aware of the potential availability of new "miracle" drugs. Currently, the demand for retrospective c-kit and HER-2 analyses can be met using the tools of traditional molecular pathology.
However, what would
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