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Troponin T better than standard enzymes for estimating extent of myocardial infarct
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One measurement of the protein troponin T 72 hours after the start of chest pain is better than using standard enzyme tests to estimate the extent of tissue damage following heart attack, concludes German research.
Creatine kinase, CK-MB, and lactate dehydrogenase require serial sampling to identify peak or cumulative serum concentrations and depend on coronary reperfusion. Furthermore, these enzymes are not exclusive to the myocardium and increases could indicate causes other than myocardial cell damage.
Enzyme activities and serum troponin T were measured after the start of chest pain in 37 patients with a first time heart attack. Blood samples were drawn every four hours on day 1, every eight hours on days 2 and 3, and then once daily until day 10. All but 14 (group 1) had early coronary reperfusion (group 2). Quantitative single photon emission computed tomography thallium-201 scintigraphy was performed at rest two to three weeks
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