© 2003 BMJ Publishing Group & Association of Clinical Pathologists
DIAGNOSTIC BRIEF
Immunohistochemical classification of B cell neoplasms
Department of Pathology, VU University Medical Center, 1081 HV Amsterdam, The Netherlands; jj.oudejans@vumc.nl
Keywords: B cell lymphoma; diagnosis; immunohistochemistry; lymphoma
| The first 150 words of the full text of this article appear below. |
In the new World Health Organisation (WHO) classification of haematological malignancies, immunophenotypical analysis is important in the subclassification of lymphomas.1 In the past decade, many new antibodies have become available that can be used on routinely fixed, paraffin wax embedded tissue sections.2,3 At present, it is possible to make a correct subclassification of B cell lymphomas in most cases using a relatively restricted set of markers. However, in some cases it may be difficult to differentiate a benign B cell response from a malignant B cell proliferation. In these cases, clonality analysis based on the presence of monoclonal immunoglobulin rearrangements is indicated. Moreover, the detection of specific translocations involving the c-myc, bcl-2, or cyclin D1 locus by molecular analysis may be required to make a definite diagnosis of Burkitt’s(like), follicular, or mantle cell lymphoma, respectively.
Whenever an immunodeficiency associated lymphoproliferative disorder is considered, RNA in situ hybridisation detecting the abundantly
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Mitterlechner, T, Fiegl, M, Muhlbock, H, Oberaigner, W, Dirnhofer, S, Tzankov, A
(2006). Epidemiology of non-Hodgkin lymphomas in Tyrol/Austria from 1991 to 2000. J. Clin. Pathol.
59: 48-55
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
