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H pylori strains from gastric MZBL have common genetic marker
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Researchers may have discovered a key determinant of a rare complication of gastric lymphoma—a virulence sequence of Helicobacter pylori—in a comparative molecular study.
They looked for genetic markers in H pylori strains isolated from patients with gastric extranodal marginal zone B cell lymphoma (MZBL) of the mucosa-associated lymphoid tissue (MALT)-type and strains from age matched patients with gastritis only. They used subtractive hybridisation, which allows genes or sequences from isolated strains to be compared with a chosen control strain. The two strains used were a "tester" gastric MZBL strain and a "driver" gastritis strain chosen as the control, which had six known H pylori virulence genes in common.
Two open reading frames (ORFs) from the hybridisation were significantly linked with gastric MZBL over gastritis strains: JHP950 (74% v 49%) and JHP1462 (26% v 3%). JHP950 proved specific for gastric MZBL when tested against a group of strains from patients with duodenal
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