© 2004 BMJ Publishing Group Ltd & Association of Clinical Pathologists
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Gene expression profiles in gastrointestinal stromal tumours
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Initial clinical features and histopathology often fail to distinguish between benign and malignant gastrointestinal stromal tumours (GISTs). These tumours probably originate in the intestinal stem cells of Cajal and it is not possible to compare gene expression profiles of the malignant tumours and the normal stem cells. Researchers in Virginia, USA have compared benign with malignant tumours.
They studied 25 GISTs, all c-KIT-positive on immunohistochemistry and with GIST histology. At diagnosis they were classified as benign (8), malignant (11), or uncertain (6). In gene array analyses performed on the first nine tumours (3 benign, 6 malignant) the expression of 1174 genes was evaluated for each sample. Compared with benign GISTs, malignant GISTs showed overexpression of 27 genes of which eight were overexpressed in five or more of the six malignant tumours. The eight genes were VIL2, COL8A1, CCNB1, HMG2, TSG101 tumour susceptibility protein, CENP-F kinetochore protein, protein tyrosine kinase 2
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