© 2004 BMJ Publishing Group Ltd & Association of Clinical Pathologists
ECHO
COX-2 is strongest predictor of early death in malignant mesothelioma
| The first 150 words of the full text of this article appear below. |
New findings may help to confirm how malignant mesothelioma develops, as cyclooxygenase-2 (COX-2) expression has been shown as a strong indicator of poor survival independently of other molecular markers previously thought to be involved.
Only expression of COX-2 (hazard ratio 1.143), not of cell cycle inhibitors p21 and p27, was significantly associated with survival of patients with mesothelioma in multivariate analysis. Univariate analysis showed that high expression of COX-2 and low expression of p21 and p27 significantly reduced survival (from median 12–14 weeks to 5 weeks). Expression of p53 tumour suppressor protein was not significant in survival, possibly because the tumours were positive for SV40 sequences. COX-2 expression was not apparently related to tumour type—whether epithelioid, sarcomucoid, or of mixed histological type—all of which were represented.
The study cohort comprised 29 selected patients from 35 original patients available for follow up, all of whom were from one region in Italy
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