EDITORIAL
Molecular pathology
Translating research into cancer molecular diagnostics and patents
Correspondence to:
Correspondence to:
Dr M Ladanyi
Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA; ladanyim@mskcc.org
Revisiting a key paper in diagnostic molecular haematopathology to mark 60 years of JCP
Keywords: molecular pathology; IGH gene; patents; polymerase chain reaction; ethics
| The first 150 words of the full text of this article appear below. |
In terms of the Diamond Jubilee celebration of the Journal of Clinical Pathology (JCP), it is evident that molecular pathology is still a relatively young field. Thus, one of the most notable papers published in the journal in this area appeared not 60 years ago, but only 15 years ago. In November 1990, in an article entitled "Monoclonality in B cell lymphoma detected in paraffin wax embedded sections using the polymerase chain reaction", Alec Morley’s group described the application of the polymerase chain reaction (PCR) to detect B cell monoclonality in formalin fixed, paraffin wax embedded material.1 This was based on the use of consensus primers for the variable and joining regions of the IGH (immunoglobulin heavy chain) gene, as illustrated in figure 1
of that paper, which has been reproduced here (fig 1). The sensitivity of the approach was documented by positive PCR results
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