SHORT REPORTS

Gastric MALT lymphoma with t(14;18)(q32;q21) involving IGH and BCL2 genes that responded to Helicobacter pylori eradication

Shotaro Nakamura¹, Hongtao Ye², Chris M Bacon², Hongxiang Liu², Alison Goatly², Takayuki Matsumoto³, Hideki Koga³, Junji Umeno³, Yutaka Ohji⁴, Takashi Yao⁴, Tsukasa Nakahara⁵, Mitsuo Iida⁶, Ming-Qing Du⁷

¹ Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
² Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK
³ Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⁴ Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⁵ Department of Internal Medicine, Kyushu Central Hospital, Fukuoka, Japan
⁶ Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
⁷ Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK

Correspondence to:
Dr S Nakamura, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; shomaka@intmedz.med.kyushu-u.ac.jp

Accepted 23 March 2007

The first 150 words of the full text of this article appear below.

Four recurrent chromosomal translocations are recognised in mucosa-associated lymphoid tissue (MALT) lymphomas: t(11;18)/API2-MALT1, t(1;14)/IGH-BCL10, t(14;18)/IGH-MALT1 and t(3;14)/IGH-FOXP1. In contrast, t(14;18)/IGH-BCL2, the genetic hallmark of follicular lymphoma, has been observed in only rare cases of MALT lymphoma. Oesophagogastroduodenoscopy revealed an ulcer in erythematous granular mucosa at the gastric corpus in a 55-year-old man. A diagnosis of MALT lymphoma was made on the basis of typical histological and immunohistochemical features of biopsy specimens: a diffuse infiltrate of centrocyte-like cells surrounding reactive lymphoid follicles and forming lymphoepithelial lesions, and a CD20+, IgD–, CD5–, CD10–, Bcl6–, cyclinD1– immunophenotype. Four months after the successful eradication of Helicobacter pylori, there was endoscopic regression with probable minimal residual disease detected by biopsy, but histological relapse was recognised 12 months after eradication. Interphase fluorescence in situ hybridisation revealed t(14;18)/IGH-BCL2. . . [Full text of this article]

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