Journal of Clinical Pathology 2007;60:1173-1177
SHORT REPORTS
Fatal circumstances of human herpesvirus 6 infection: transcriptosome data analysis suggests caution in implicating HHV-6 in the cause of death
1 Institute of Pathology, Medical University of Innsbruck, Austria
2 Department of Virology, University Hospital, Heidelberg, Germany
3 Institute of Forensic Medicine, University Hospital, Heidelberg, Germany
4 Central Medical Institute of Federal Armed Forces, Koblenz, Germany
5 Department of Virology, University Hospital, Heidelberg, Germany
Professor Consolato Sergi, Medical University Innsbruck, Muellerstrasse 44, AT-6020 Innsbruck, Austria; consolato.sergi@i-med.ac.at
Accepted 18 May 2007
| The first 150 words of the full text of this article appear below. |
Human herpesvirus 6 (HHV-6), a T-lymphotropic enveloped double stranded DNA virus of the Herpesviridae family, can be divided into two major variants, designated A and B. The B variant is associated with exanthema subitum (roseola infantum, 6th disease), characterised by fever and lymphadenopathy, followed or not by a maculo-papular rash primarily on the neck and trunk. HHV-6, however, is also an important opportunistic agent in patients with impaired immune systems. In recent years, increased antibody titres and positive amplification of the viral genome by PCR have been shown in chronic fatigue syndrome, lymphoproliferative diseases, autoimmune thyroiditis, Sjögren syndrome, rheumatoid arthritis, Crohn’s disease, and sarcoidosis.1 Complications of primary infection in infancy and childhood and simultaneous occurrence of sudden death or short-term mortality include pneumonitis, hepatosplenomegaly, fulminant hepatitis, aseptic meningitis, intussusception, thrombocytopenic purpura, fatal haemophagocytic syndrome, and disseminated infection.2–4
However, the aetiological contribution of the virus in fatal cases is still debated
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