CASE REPORT
Infection-associated haemophagocytic syndrome associated with recurrent acute myeloid leukaemia/myelodysplastic syndrome: an autopsy case
Department of Medicine, Section of Hematology/Oncology, East Orange VA Medical Center/UMDNJ-NJMS, East Orange, New Jersey, USA
Correspondence to:
Correspondence to:
R B Malliah
Department of Pathology and Laboratory Medicine, UMDNJ-NJMS, Room E156, 15o Bergen St., Newark, NJ 07103, USA; malliara@umdnj.edu
Accepted 25 July 2005
Abbreviations: AML, acute myeloid leukaemia; IAHS, infection-associated haemophagocytic syndrome; MDS, myelodysplastic syndrome
| The first 150 words of the full text of this article appear below. |
Infection-associated haemophagocytic syndrome (IAHS) is an uncommon disorder usually occurring in immunocompromised patients. IAHS is a systemic reactive proliferation of phagocytic histiocytes induced by an infection usually of viral origin.1 We report a fatal case of IAHS arising in a patient with recurrent acute myeloid leukaemia (AML)/myelodysplastic syndrome (MDS). The diagnosis of IAHS was made after autopsy and histological evaluation of tissue.
A 60-year-old man with a history of acute myelogenous leukaemia (M4 myelomonocytic leukaemia) status post complete remission after chemotherapy 5 years ago was admitted for progressive fatigue and pancytopenia. He was in good health until 1 year ago when he started to develop macrocytic anaemia and thrombocytopenia. A bone marrow biopsy at that time showed changes consistent with myelodysplastic syndrome (refractory anaemia). Over the next few months, he developed a progressive pancytopenia but did not come in for evaluation. He was admitted to his local hospital 1 month
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