COMMENTARY

Squamous intraepithelial lesions

Our approach to squamous intraepithelial lesions of the uterine cervix

Alexandra N Kalof, Kumarasen Cooper

University of Vermont, Burlington, Vermont, USA

Correspondence to:
Dr A N Kalof
Department of Pathology, University of Vermont, Fletcher Allen Health Care, ACC-E2-108, 111 Colchester Avenue, Burlington, VT 05401, USA; alexandra.kalof@vtmednet.org

Accepted 28 September 2006

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Morphological analysis remains the "gold standard" in the diagnosis and grading of CIN

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The first 150 words of the full text of this article appear below.

Cervical carcinoma is a significant contributor to cancer-related morbidity and mortality worldwide and the role of human papillomavirus (HPV) in the development of preinvasive and invasive cervical lesions is well established.^1,2 Although significant advances have been made in elucidating the potential mechanisms of cellular transformation by HPV and in the molecular detection of HPV in cytological and surgical specimens, morphological assessment of surgical material remains the "gold standard" in the diagnosis of cervical intraepithelial neoplasia (CIN). Although management of preinvasive cervical disease depends on many factors including the age of the patient, parity and size of the lesion, clinical management often requires confirmation of CIN by histological examination with subsequent surgical treatment of high-grade lesions (CIN 2 or CIN 3). This has fueled attempts at more objective, reproducible diagnostic parameters to accurately diagnose CIN. The histological features of preinvasive cervical neoplasia (CIN 2 and 3) are well . . . [Full text of this article]

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