Journal of Clinical Pathology 2007;60:843-844
SHORT REPORT
Histopathological features of gastrointestinal mucosal biopsy specimens in children with epidermolysis bullosa
1 Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK
2 Department of Paediatric Dermatology, Great Ormond Street Hospital, London, UK
3 Department of Histopathology, Great Ormond Street Hospital, London, UK
4 Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK
5 Department of Histopathology, Great Ormond Street Hospital, London, UK
Correspondence to:
Dr N Shah
Consultant Paediatric Gastroenterologist, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH; ShahN@gosh.nhs.uk
Accepted 5 January 2006
Keywords: epidermolysis bullosa; inflammation; apoptosis
| The first 150 words of the full text of this article appear below. |
Epidermolysis bullosa (EB) is a term used to represent a group of conditions characterised by cutaneous blistering due to abnormalities of ultrastructural components anchoring epithelial cells to either each other or to the basement membrane.1–3 There are a range of subtypes, which were traditionally classified on the basis of the level of the epidermal separation, more recently delineated on the basis of the underlying genetic defect.4 The vast majority of the clinical literature in these conditions is based around the cutaneous complications. There is a reported association between some subtypes of epidermolysis bullosa and pyloric stenosis,4 but there are no previous reports of mucosal histopathological features, despite these patients sometimes exhibiting significant gastrointestinal symptoms.
We report the gastrointestinal mucosal histopathological features in a series of patients with epidermolysis bullosa who underwent endoscopic evaluation for gastrointestinal symptoms at a single specialist centre.
Since 2003 it has been our policy to investigate
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
jcp.2005.035766v1
60/7/843 most recent - Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
