Abstract

Alkali denaturation of the haemoglobin derived from burned patients at various intervals from the time of the injury was investigated. A delayed denaturation curve was always found.

The involvement of the transfused cells was established by a differential agglutination technique.

Red cell populations were fractionated into two portions, one of which was probably enriched in younger cells. This portion was preferentially affected.

A starch gel technique yielded a “slow” and a “fast” fraction of haemoglobin with differing denaturation rates, even in normals. The “slow” fraction appeared to be increased quantitatively and qualitatively, if compared with normal blood.