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THE RELATIONSHIP OF SERUM GAMMA-GLOBULIN CONCENTRATION TO MALARIA AND SICKLING
  1. J. C. Edozien,
  2. A. E. Boyo,
  3. D. C. Morley
  1. Department of Chemical Pathology, University College, Ibadan
  2. Wesley Guild Hospital, Ilesha, Western Nigeria

    Abstract

    The serum protein patterns of groups of Nigerians including 98 children partially protected by “daraprim” against malaria, and 113 unprotected children, have been studied.

    The protected children have a significantly lower concentration of serum γ globulin than the unprotected children from the age of 12 months onwards.

    In children, sicklers have a significantly higher serum γ globulin than non-sicklers.

    It is suggested that sickling protects against malaria by enhancing the antibody response against the malaria parasite.

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