The absorption of 60CoB12 has been studied in a group of patients suffering from megaloblastic anaemia associated with pregnancy and in a control group.
The mean urinary excretion of 60CoB12 in the patients with megaloblastic anaemia is not significantly different from that of the control group. Five of the 30 patients showed a value towards the lower limit of normal, but the serum vitamin B12 content in this group was within the normal range.
Malabsorption of vitamin B12 does not appear to play a significant role in the pathogenesis of this form of megaloblastic anaemia.
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