Evidence is presented that after injection of radioactive vitamin B12 in man, there is a close correlation between the amount of radioactivity excreted and the amount of assayable vitamin B12 excreted, and thus that the amount of radioactivity excreted is a true measure of the vitamin B12 excreted. The possible reasons for this occurrence are discussed and it is suggested that in the body vitamin B12 does not exist as such but as an analogue or active derivative.
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