A modified method of estimating the antistreptolysin O titre (A.S.O.) is described. The A.S.O. of 279 sera from normal children under 5 years of age is recorded, together with that of 40 children over 5 years of age. The results show a range much lower than that found in adults and older children and are discussed with respect to estimations made in children with proven infections. The significance of these findings is discussed.
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