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Hereditary elliptocytic anaemia
  1. R. J. L. Davidson,
  2. W. T. Strauss
  1. Department of Pathology, Queen's College, Dundee
  2. Department of Medicine, Queen's College, Dundee

    Abstract

    A sibship with four cases of hereditary elliptocytic anaemia is described. The condition in this family may have arisen as a mutation in the mother of the sibship; affected members were unable to taste phenylthiocarbamide while normal members were tasters.

    Experiments with 32P-orthophosphate in vitro did not show any evidence of biochemical upset as found in hereditary spherocytosis; thus a combination of congenital spherocytosis and elliptocytosis cannot be supported as the cause of the haemolytic state. Clinical evidence of haemolytic disease was accompanied by a tendency to excessive lysis in vitro.

    Infection may play a part in the precipitation of anaemic crises in this as in other hereditary haemolytic anaemias.

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