The Fe59 method of Suit (1957) has been used to estimate total bone marrow cellularity in 10 haematologically normal patients. A mean figure of 10·4 × 109 nucleated cells/kg. body weight was obtained. Simultaneous estimates from marrow obtained by rib excision produced a mean value of 11·1 × 109 nucleated cells/kg.
Previous work by this and other methods is reviewed. While some results agree well with those of the present work, one is higher by 50% and another by 300%. Corrections are suggested which reduce these figures and bring all published results within a small range.
Reasonably accurate determinations of total marrow cellularity in disease will not be possible until more is known of marrow Fe59 uptake in abnormal states.
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↵1 Based on a paper read at a meeting of the Association of Clinical Pathologists on 22 September 1961.
2 Present address: Department of Morbid Anatomy, Westminster Hospital Medical School, London, S.W.1.
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