Article Text

PDF

Reticulocyte release factor
  1. Hillas Smith
  1. Institute of Clinical Research, Middlesex Hospital Medical School, London

    Abstract

    Some investigators have had conspicuous success with reticulocyte counting methods in animals as assay techniques for plasma erythropoietic hormone, but there has been some diversity in the reticulocytosis obtained by different workers.

    This communication reports the disparity between the marrow erythroid activity (assessed by counting colchicine-blocked mitoses) and the reticulocyte response in normal Wistar rats injected with plasma extracts. In bled rats in which mitotic activity was of comparable range to the extract-injected rats a considerable reticulocytosis resulted. Evidence is presented that the most likely explanation for the lack of reticulocytosis in the injected group is the absence of a factor necessary for the release of reticulocytes.

    It is emphasized that in assay methods using reticulocyte counts, weight, age, and strain of the animals may be of critical importance.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.