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The histogenesis of carcinoid tumours of the rectum
  1. N. M. Gibbs
  1. Royal Surrey County Hospital, Guildford
  2. St. Mark's Hospital, London

    Abstract

    `Carcinoid' tumours of the rectum have been described which are classified on histological appearances into three main varieties: `true' carcinoid or argentaffinoma, `atypical' or non-argentaffin carcinoid, and `composite carcinoid. The histogenesis of these tumours is discussed and it is suggested that non-argentaffin carcinoids of the rectum have an essentially similar histogenesis to certain tumours of the lung, pancreas, and gastrointestinal tract. The difference in growth, pattern, and staining reactions are a reflection of differing directions and levels of differentiation of the parent epithelium. The functional implications of this hypothesis are discussed.

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