Article Text

The histogenesis of carcinoid tumours of the rectum
1. N. M. Gibbs
1. Royal Surrey County Hospital, Guildford
2. St. Mark's Hospital, London

## Abstract

Carcinoid' tumours of the rectum have been described which are classified on histological appearances into three main varieties: true' carcinoid or argentaffinoma, atypical' or non-argentaffin carcinoid, and composite carcinoid. The histogenesis of these tumours is discussed and it is suggested that non-argentaffin carcinoids of the rectum have an essentially similar histogenesis to certain tumours of the lung, pancreas, and gastrointestinal tract. The difference in growth, pattern, and staining reactions are a reflection of differing directions and levels of differentiation of the parent epithelium. The functional implications of this hypothesis are discussed.

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