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Synergism between sulphonamide drugs and antibiotics of the polymyxin group against Proteus sp. in vitro
  1. F. E. Russell
  1. Bacteriology Department, University and Western Infirmary, Glasgow
  2. Infectious Diseases Hospital, Paisley

    Abstract

    Interesting synergism in vitro between a recently introduced antibiotic, colistin methane sulphonate, and sulphonamide drugs is described. The observations were extended to polymyxin B sulphate and sulphonamides with essentially similar results. The combinations are bactericidal at therapeutic levels, the ratio of drugs to one another is not critical, and the effect is present over a fairly wide pH range.

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