The 24-hour urinary output of 3-methoxy-4-hydroxy mandelic acid (V.M.A.) has been determined in 20 normal adults, 150 hypertensive patients, and four cases of phaeochromocytoma. In this last group estimations of urinary catecholamines and total urinary methylated amines were also performed and the overall results have been compared with the urinary excretory pattern of catecholamines and their metabolites following the injection of radioactive adrenaline and noradrenaline.
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