Three cases of carcinoma of the thyroid have been found in a post-mortem study of 37 cases of myxoedema. Each example of invasive carcinoma was accompanied by more widespread epithelial abnormalities which, though histologically similar, were not themselves demonstrably malignant.
It is probable that in myxoedema, as in chronic thyroiditis, excessive secretion of thyrotropic hormone leads to an increased susceptibility to carcinoma of the thyroid.
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