Sodium-α-naphthylamine-4-sulphonate (Naphthionin) appears to shorten the bleeding time in normal subjects and to be of value in the management of the bleeding defect in patients with thrombocytopenia when given by intravenous or intramuscular injection. A good response was achieved in three patients suffering from severe haemorrhage and the prolonged bleeding time in other cases of thrombocytopenia was shortened. There is no evidence that Naphthionin is of value in haemostasis in other patients in whom haemorrhage is not due directly to thrombocytopenia.
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↵1 Since the paper was written a failure has been encountered with the drug in a case of aplastic anaemia and thrombocytopenia following the administration of Thiotepa. This may be due to alteration of the fibrinogen molecule by Thiotepa.
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