Spinal fluid lactate dehydrogenase (L.D.H.) isoenzyme patterns have been investigated in normal subjects, in those with non-destructive nervous disease, and in those with destructive lesions in the nervous system.
The spinal fluid from organic disease in general showed a significantly increased level of L.D.H.2 and L.D.H.3 so that the combined values of L.D.H.2 and L.D.H.3 might perhaps be of value in determining the presence of destructive nervous lesions.
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