Nine cases of diffuse membranous glomerulonephritis detected among 90 renal biopsies from children with persistent proteinuria and one necropsy case of a young child who died of chronic membranous glomerulonephritis with uraemia were studied by a variety of techniques. Clinical presentation varies within this single morphological entity and the response to steroid therapy is not yet predictable on either clinical or morphological criteria. Correlation is demonstrated between therapeutic responses and the degree of selectivity of the proteinuria which was determined by studying the relative protein clearances with an immunochemical technique.
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