Cervical biopsies from 97 women with malignant cells in cervical scrape smears have been studied. Forty-eight patients had invasive squamous carcinoma, and 49 had intraepithelial lesions. Of these, six had dedifferentiated carcinoma in situ, nine had the differentiated lesions generally known as `severe dysplasia', and 29 had both; the severity of the dysplasia remained doubtful in five patients.
The `severe dysplasia' was compared with invasive carcinoma. A cellular analysis of the biopsies showed that the two categories have a number of features in common, chiefly the presence of atypical and normal mitoses, nucleoli, horn cells, and giant cells. The stratification of the epithelium in `severe dysplasia' is invariably abnormal and the architecture closely resembles that of invasive carcinoma. The cells in the smears from `severe dysplasia' are similar to those in invasive carcinoma.
It is suggested on the basis of these observations that a `severe dysplasia' should be interpreted as a differentiated carcinoma in situ.
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A cyto-histological correlation of malignant intraepithelial lesions with invasive carcinoma
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