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Squamous differentiation in carcinoma in situ of the cervix uteri
  1. Chandra Grubb,
  2. Ivan Janota1
  1. Department of Pathology, The Royal Free Hospital, Gray's Inn Road, London


    Cervical biopsies from 97 women with malignant cells in cervical scrape smears have been studied. Forty-eight patients had invasive squamous carcinoma, and 49 had intraepithelial lesions. Of these, six had dedifferentiated carcinoma in situ, nine had the differentiated lesions generally known as `severe dysplasia', and 29 had both; the severity of the dysplasia remained doubtful in five patients.

    The `severe dysplasia' was compared with invasive carcinoma. A cellular analysis of the biopsies showed that the two categories have a number of features in common, chiefly the presence of atypical and normal mitoses, nucleoli, horn cells, and giant cells. The stratification of the epithelium in `severe dysplasia' is invariably abnormal and the architecture closely resembles that of invasive carcinoma. The cells in the smears from `severe dysplasia' are similar to those in invasive carcinoma.

    It is suggested on the basis of these observations that a `severe dysplasia' should be interpreted as a differentiated carcinoma in situ.

    Statistics from

    A cyto-histological correlation of malignant intraepithelial lesions with invasive carcinoma


    • 1 Present address: Department of Neuropathology, Institute of Psychiatry, The Maudsley Hospital, London.

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