Article Text

PDF

Effect of diluents on blood clot lysis
  1. M. J. Gallimore
  1. Department of Biochemical Pharmacology, Pfizer Limited, Sandwich, Kent
  2. Therapeutics Research Division, Pfizer Limited, Sandwich, Kent

    Abstract

    One of the current methods used for measuring natural fibrinolytic activity in blood involves dilution of the blood with phosphate buffer. An adaptation of this method using a solution of sodium acetate as diluent is described. Evidence is given to show that dilute blood clots lyse not only because of the dissociation of an antiplasmin-plasmin complex, but also by virtue of a reduction of the intrinsic chloride ion concentration.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.