Article Text

PDF

An investigation of three patients with Christmas disease due to an abnormal type of factor ix
  1. K. W. E. Denson,
  2. Rosemary Biggs,
  3. P. M. Mannucci1
  1. Medical Research Council, Churchill Hospital, Oxford
  2. Blood Coagulation Research Unit, Churchill Hospital, Oxford

    Abstract

    Three patients with Christmas disease whose plasma was shown to have a prolonged one-stage prothrombin time with ox brain thromboplastin have been investigated. These patients have an inhibitor for the reaction between factor X, factor VII, and ox brain extract. The abnormal constituent responsible for this inhibitor appears to be factor IX whuch is functionally inactive but antigenically indistinguishable from normal factor IX. It is proposed that patients might be classified into haemophilia B+ for patients with this defect (Christmas disease+) and haemophilia B (Christmas disease) for patients who have classical Christmas disease.

    Statistics from Altmetric.com

    Footnotes

    • 1 Present address: Instituto Patologia Medica, Ospedale Civelie, Cagliari, Italy.

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.