Article Text

PDF

Role of lipoproteins in the formation of spur cell anaemia
  1. Manuel Martinez-Maldonado
  1. Medical Service, San Juan Veterans Administration Hospital, San Juan, Puerto Rico
  2. Department of Medicine, University of Puerto Rico School of Medicine, San Juan, Puerto Rico

    Abstract

    The case of a patient with cirrhosis of the liver suffering from severe haemolysis accompanied by circulating `spur cells' is described. Studies performed in an attempt to determine the cause for the abnormal shape of the erythrocytes demonstrated that the patient's serum could induce spur formation in normal compatible cells. Several lines of evidence pointed to the possibility that the factor inducing the spurs was a protein. By column chromatography and gradient ultracentrifugation it was shown that the patient's low density lipoproteins could induce spurs to form in normal cells.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.