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Immunofluorescent localization of Tamm-Horsfall mucoprotein in human kidney
  1. J. K. McKenzie1,
  2. E. G. McQueen
  1. Wellcome Medical Research Institute, University of Otago Medical School, Dunedin, New Zealand
  2. Department of Medicine, University of Otago Medical School, Dunedin, New Zealand
  3. Department of Pharmacology, University of Otago Medical School, Dunedin, New Zealand

    Abstract

    A fluorescein-labelled antiserum to human Tamm-Horsfall mucoprotein applied to frozen human kidney sections gave strong specific labelling, mainly of cells of tubules in the outer medulla. By comparison with adjacent serial sections stained for alkaline phosphatase and succinic dehydrogenase, it is suggested that material reacting immunologically as Tamm-Horsfall muco-protein is found particularly in the cells of the ascending limb of the loop of Henle and the macula densa segment of the distal tubule.

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    Footnotes

    • 1 Present Address: Department of Medicine, Medical College, Winnipeg, Manitoba.

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