Article Text

PDF

Investigation of ketoacidurias by two-dimensional paper chromatography
  1. R. F. Coward,
  2. P. Smith,
  3. J. W. T. Seakins
  1. RAF Institute of Aviation Medicine, Farnborough, Hants
  2. Institute of Child Health, London

    Abstract

    A simple paper chromatographic method was found to be effective for the study of phenylketonuria and tyrosyluria. It proved to be much more reliable than conventional tests for the detection of abnormal amounts of ketoacids in urine and was suitable and convenient for following the effects of dietary variations on the excretion of these compounds. Information obtained about ketones other than those of primary importance to the conditions studied included confirmation of the excretion of p-hydroxyphenylpyruvic acid in phenylketonuria. A modification of the method applicable to histidinaemia was devised.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.