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Structure and ultrastructure of the labial salivary glands in patients with cystic fibrosis
  1. R. G. Doggett1,
  2. B. Bentinck2,
  3. G. M. Harrison
  1. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
  2. Department of Rehabilitation, Baylor College of Medicine, Houston, Texas, USA
  3. Texas Institute for Rehabilitation and Research, Houston, Texas, USA

    Abstract

    The morphology of the labial salivary glands in subjects with and without cystic fibrosis has been studied by light and electron microscopy. The terms `light' cell, `dark' cell, `clear' cell, and `myoepithelial' cell are used to describe the four cell types distinguished at the level of the electron microscope. The dark cells were found to stain specifically with alcian blue at and above pH 1·0, and the light cells to stain specifically using the periodic acid-Schiff (PAS) technique. This staining reaction suggests that an acidic mucosubstance is being produced by the dark cells and a neutral mucosubstance by the light cells. While no marked morphological differences were observed in the labial glands of patients with cystic fibrosis when contrasted with normal controls, it was observed that the cells from patients with cystic fibrosis contained quantitatively more mucus.

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    Footnotes

    • 1 Please send requests for reprints to R. G. Doggett, Texas Institute for Rehabilitation and Research, 1333 Moursund Avenue, Houston, Texas.

    • 2 Present address: Methodist Hospital, Texas Medical Center, Houston Texas 77025.

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